FIELD: organic chemistry, pharmacology.
SUBSTANCE: claimed method includes reaction of alginic acid with amine-containing compound (RNH2) in presence of condensing agent 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide in aqueous medium at room temperature and pH 4.7-4.8. As amine-containing compounds some pharmacologically value amines are used such as n- and o-aminophenols, 5- and 4-amino salicylic acids, anthranilic acid, and n-aminobenzoic acid, n-aminobenzoic acid ethyl ester (anaesthezine), n-aminobenzoic acid β-diethylaminoethyl ester (novocaine), nicotinic acid 1-phenyl-2,3-dimethyl-4-aminopyrazolone-5-(4-aminopyrine) hydrazide (isoniaside), 2-amino'thansulfonic acid (taurin), 7-aminocephalosporinic acid, as well as sulfanylamide preparations such as n-aminobenzenesulfacetamide (streptocide), sodium n-aminobenzenesulfacetamide (sodium sulfacyl).
EFFECT: new alginic acid derivatives useful in medicine and pharmacology.
1 cl, 14 ex, 1 tbl
| Title | Year | Author | Number |
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| METHOD FOR PRODUCTION OF MODIFIED ARABINOGALACTAN | 2007 |
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|
RU2076127C1 |
| 0 |
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SU459886A3 |
