METHOD FOR PRODUCTION OF MODIFIED ARABINOGALACTAN Russian patent published in 2009 - IPC C08B37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to new derivants of arabinogalactan. The method for production of modified arabinogalactan by oxygenising its primary hydroxy groups with system of 2,2,6,6,-tetramethylpiperydine-1-oxyl radical NaBr-NaClO-H₂O with pH 10.2 to carboxyl groups and further conjugation of carboxy groups of oxidised arabinogalactan with amino containing compounds in the presence of condensing agent 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide in aqueous medium at the ambient temperature and pH 4.7-4.8 is described. A number of pharmaceutically important amines are used as amino containing compounds: n- and o-aminophenols , 5- and 4-aminosalicylic, anthroic and n-aminobenzoic acids, ethyl ester of n-aminobenzoinc acid (benzocaine), (3-diethylaminoethyl ester of n-n-aminobenzoinc acid (ethocaine hydrochloride), 1-phenyl-2,3-dimethul-4-amonipyrazolon-5(4-aminoantipyrine), isonicotinic acid hydrazide (isoniaside), sulfanamides, such as n-sulphanilamide (streptocide), n-aminobenzolsulfacetamide-sodium (sulfacyl sodium), 2-aminoethanesulfonic acid (taurine), natural α-amino acids (amino acetic acid, diamino-hexanoic acod, etc), diamines (hydrazine, ethylene diamine) and dihydrazides (dehydrazide of hexandioic acid). The derivants of arabinogalactan which can be used in medicine and pharmacology are derived. Conversion of carboxygroups to amide groups of oxidised arabinogalactan achieves 90-95%.

EFFECT: invention can be applied in medicine, pharmacology

1 cl, 2 dwg, 1 tbl, 15 ex