FIELD: medicine, pharmacology.
SUBSTANCE: invention relates to method for production of modified Dermathane sulfate (DS) by interaction thereof with animo-containing compounds in aqueous medium at pH 4.7-4.8 in presence of condensing agent such as 1-ethyl-3[3-(dimethylamino)propyl]carbodiimide (EDC). As animo-containing compounds substances of general formula RNH2 are used, wherein R is C6H4OH (p- or o-aminophenol residues), C6H4COOH (p-aminobenzoic or anthranilic acid residues), C6H3(OH)COOH (4- or 5-aminosalicilic acid residues), etc., such as defined in specification, in molar component ratio of DS:RNH2:EDC = 1:1:(0.75-1.50) followed by purification from low molecular components.
EFFECT: dermathane sulfate derivatives useful in medicine and pharmacology.
1 tbl, 2 ex
| Title | Year | Author | Number |
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