FIELD: organic chemistry, biochemistry, virology.
SUBSTANCE: invention relates to inhibition of human immunodeficiency virus (HIV) that is identified as etiological agent responsible for the acquired immunodeficiency syndrome (AIDS) that represents the lethal disease characterizing by damage of immune system, inability for the life safe and to resist against infections. Invention proposes inhibitors of integrase represented by the formula (I):
wherein corresponding values of radicals are given in the invention description. The aim of the present invention involves providing preparing a pharmaceutical composition useful for inhibition of activity of HIV integrase that involves the therapeutically effective dose of compound of the formula (I) and their pharmaceutically acceptable salts, solvates and a pharmaceutically acceptable carrier.
EFFECT: valuable medicinal properties of inhibitors.
16 cl, 6 sch, 42 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF AZETIDINE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION AND MEDICINAL AGENT BASED ON THEREOF | 1999 |
|
RU2230739C2 |
| METHOD FOR PREPARING 5,8,9,10-TETRAHYDROPYRIMIDINO[4,5-d]AZOCINE DERIVATIVES HAVING TRIFLATE, SECONDARY AND TERTIARY AMINO GROUPS IN 4-TH POSITION | 2011 |
|
RU2478637C2 |
| METHOD OF PRODUCING SULFANYL DERIVATIVES OF ANTIPYRINE | 2020 |
|
RU2740911C1 |
| METHOD OF PRODUCING Α-DIAZOCARBONYL COMPOUNDS IN AQUEOUS MEDIUM | 2018 |
|
RU2686489C1 |
| COMPOUNDS - SULFAMATE DERIVATIVES FOR USE IN TREATING OR RELIEVING PAIN | 2014 |
|
RU2699025C1 |
| DERIVATIVES OF PIPERIDINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS | 1997 |
|
RU2193029C2 |
| NEW PHTHALAZINE DERIVATIVES AND ITS PRODUCTION PROCESS | 2014 |
|
RU2636585C2 |
| AMINOPYRAZOLOPYRIMIDINE COMPOUND USED AS INHIBITOR OF TYROSINE KINASE RECEPTOR OF NEUROTROPHIC FACTOR | 2017 |
|
RU2764523C2 |
| COMPOUNDS HAVING MUSCARINIC RECEPTOR AGONIST AND BETA-2-ADRENERGIC RECEPTOR AGONIST ACTIVITY | 2016 |
|
RU2709777C2 |
| DERIVATIVES OF INDOLIN-2-SHE AS INHIBITORS OF PROTEINKINAS | 2013 |
|
RU2627706C2 |
