DERIVATIVES OF PIPERIDINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to derivatives of piperidine of the general formula (1) and their pharmaceutically acceptable salts where R¹ means hydrogen atom, C₁-C₆-alkyl, C₂-C₆-alkenyl, C₃-C₈-cycloalkyl, C₆-C₁₀-aryl that can be substituted with CH₃, halogen atom, OR⁵ where R⁵ means C₁-C₆-alkyl, (C₁-C₂)-alkyl-heteroaryl comprising S, N or O as heteroatom; A means phenyl substituted with carbonyl or amino-group; B means C₆-C₁₀-aryl or C₅-C₁₀-heteroaryl comprising S, N or O as heteroatom. Invention relates to method of synthesis of compounds of the formula (1) and pharmaceutical compositions also. Compounds of the formula (1) show analgetic activity and can be used in medicine. EFFECT: improved method of synthesis, valuable medicinal properties. 11 cl, 2 tbl, 68 ex