IMIDAQZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR INHIBITION OF CELL PROLIFERATION, METHOD FOR THEIR PREPARING (VARIANTS), USING, PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING Russian patent published in 2006 - IPC C07D403/04 C07D403/14 C07D401/14 C07D407/14 C07D413/14 C07D417/14 A61K31/506 A61K31/5355 A61P35/02 C07D239/00 C07D233/00 C07D295/00 C07D241/00 C07D277/00 C07D261/00 C07D317/08 C07D207/00 

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to compounds of the formula (I)

or their pharmaceutically acceptable salts or esters hydrolyzing in vivo and possessing activity inhibiting the cellular cycle and selective with respect to CDK-2, CDK-4 and CDK-6. Compounds can be used in cancer treatment. In the formula (I) R¹ represents halogen atom, amino-group, (C₁-C)-alkyl, (C₁-C₆)-alkoxy-group; p = 0-4 wherein values R¹ can be similar or different; R² represents sulfamoyl or group R^a-R^b-; q = 0-2 wherein values R² can be similar or different and wherein p + q = 0-5; R³ represents halogen atom or cyano-group; n = 0-2 wherein values R³ can be similar or different; R⁴ represents hydrogen atom, (C₁-C₆)-alkyl, (C₂-C₆)-alkenyl, (C₂-C₆)-alkynyl, (C₃-C₈)-cycloalkyl, phenyl or heterocyclic group bound with carbon atom wherein R⁴ can be optionally substituted at carbon atom with one or some groups R^d; R⁵ and R⁶ are chosen independently from hydrogen, halogen atom, (C₁-C)-alkyl, (C₂-C₆)-alkenyl or (C₃-C₈)-cycloalkyl wherein R⁵ and R⁶ can be substituted at carbon atom independently of one another with one or some groups R^e; R^a is chosen from (C₁-C₆)-alkyl, (C₂-C₆)-alkenyl, (C₂-C₆)-alkynyl, (C₃-C₈)-cycloalkyl, (C₃-C₈)-cycloalkyl-(C₁-C₆)-alkyl, phenyl, heterocyclic group, phenyl-(C₁-C)-alkyl or (heterocyclic group)-(C₁-C₆)-alkyl wherein R^a can be substituted optionally at carbon atom with one or some groups R^g and wherein if indicated heterocyclic group comprises residue -NH- then its nitrogen atom can be optionally substituted with group chosen from the group R^h; R^b represents -N(R^m)C(O)-, -C(O)N(R^m)-, -S(O)_r-, -OC(O)N(R^m)SO₂-, -SO₂N(R^m)- or -N(R^m)SO₂- wherein R^m represents hydrogen atom or (C₁-C₆)-alkyl, and r = 1-2. Also, invention relates to methods for synthesis of these compounds, a pharmaceutical composition, method for inhibition and using these compounds.

EFFECT: improved preparing method, valuable medicinal properties of compounds and pharmaceutical compositions.

24 cl, 3 sch, 166 ex