BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY Russian patent published in 2018 - IPC C07D403/06 C07D403/12 C07D403/14 C07D413/14 C07D471/04 C07D471/10 A61K31/496 A61K31/5025 A61K31/5377 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (Ic) or its tautomeric or stereochemically isomeric forms, N-oxides or pharmaceutically acceptable salts. In formula (Ic), A is CH, U is CR⁸ and V is N, or A is CH, U is N and V is CR⁹, or A is N, U is CR⁸ and V is CR⁹, or A is CH, U is CR⁸ and V is CR⁹; R¹ is selected from C_1-4alkyl optionally substituted with 1, 2 or 3 halogen atoms; R^3a is selected from hydrogen, C_1-6 alkyl, -C(=O)NH_(2-q)(C_1-6 alkyl)_q, -CH₂-(5-6-membered aromatic or non-aromatic heterocyclyl), -CH₂-(9-10-membered bicyclic aromatic or non-aromatic heterocyclyl), and -C(=O)-(4-6-membered aromatic or non-aromatic heterocyclyl); R⁶ and R⁷ are independently selected from hydrogen, C_1-6 alkyl, -CH₂-phenyl, -CH₂-O-CH₂-phenyl, or groups R⁶ and R⁷, together with the carbon atom with which they are bound, can be combined to form a 3- to 6-membered saturated carbocyclic or heterocyclic group, selected from cyclopropyl, cyclobutyl, cyclopentyl, azetidine, piperidine, which, optionally, may be fused to a phenyl ring. Other radical values are presented in the patent claim. Invention also relates to individual compounds, a pharmaceutical composition, to the use of the compound and to methods for its preparation. (Ic)

EFFECT: technical result: obtaining novel compounds of formula (Ic), which can be useful for the prevention or treatment of a disease or condition mediated by one or more IAP family proteins.

55 cl, 10 tbl, 266 ex