HYDROXYBENZAMIDE DERIVATIVES AND USE THEREOF AS Hsp90 INHIBITORS Russian patent published in 2012 - IPC C07D209/44 C07D401/04 C07D413/04 A61K31/4035 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of formula (VI): or its pharmaceutically acceptable salts; wherein n is equal to 0, 1, 2 or 3; R¹ means -OH, H; R^2a means OH, -CH₃, provided at least one of R¹ and R^2a means -OH;R³ means Cl, Br, cyclopropyl, branched C_3-5alkyl R^4a means H; R⁸ means H; wherein the fragment: may be one of the groups B8, B35, B36, B37, B38, B39, B40, B41, B42, B43, B45, B46, B48, B54, B56, B58, B59, B61, B62, B71, B72, B74, B75, B76, B77, B78, B79, B80, B81, B82, B84, B86, B87, B88, B89, B90, B91, B93, B94, B95, B96, B97, B98, B99, B100 and B101 wherein the values are disclosed in the patent claim 1.

EFFECT: compounds show Hsp90 inhibitory activity that enables using them for treating the diseases caused by abnormal cell growth in mammals.

26 cl, 8 dwg, 2 tbl, 82 ex