FIELD: pharmaceuticals, in particular topical drugs for treatment of skin and mucous membrane disorders.
SUBSTANCE: invention relates to metronidazole aqueous solution for production of pharmaceutical composition having physical stability for at least one week at 5°C and metronidazole concentration of 0.75 %. Said solution contains combination of agents enhancing solubility, wherein one agent represents cyclodextrin, such as beta-cyclodextrin, and another one represents compound differ from cyclodextrin. Methods of production and therapeutic application of abovementioned solutions also are described.
EFFECT: physically stable metronidazole aqueous solutions containing minimized amount of cyclodextrins.
48 cl, 6 tbl, 5 ex
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