FIELD: organic chemistry, chemical technology, organic synthesis.
SUBSTANCE: method involves the dihydrochlorination and isomerization reactions of 7,7-dichloro[4.1.0]heptane by effect with copper mono- and bivalent salts and alcohol of the formula: ROH wherein R means methyl (Me) or ethyl (Et) wherein alcohol acts as a HCl-binding reagent in the mole ratio of components [7,7-dichlorobicyclo[4.1.0]-heptane] : [ROH] : [cat] = 1:10:0.01, respectively, at temperature 60°C for 6 h. Invention provides increasing yield and purity of the end product and simplifying equipment requirement of the process.
EFFECT: improved method of synthesis.
1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING N-CONTAINING BICYCLO[4_2_1]NONA-2,4,7-TRIENES EXHIBITING ANTITUMOUR ACTIVITY | 2019 |
|
RU2735662C1 |
| 0 |
|
SU174621A1 | |
| METHOD FOR COMBINED PRODUCTION OF PENTACYCLO[7.5.0.0.0.0]TETRADECA-3,12-DIENE AND PENTACYCLO[8.4.0.0.0.0]TETRADECA-8,12-DIENE | 2013 |
|
RU2551282C1 |
| METHOD OF PRODUCING PENTACYCLO[8.4.0.0.0.0]TETRADECA-8,12-DIENE | 2013 |
|
RU2551280C1 |
| METHOD OF PRODUCING SI-CONTAINING BICYCLO[4_2_1]NONA-2,4,7-TRIENES EXHIBITING ANTITUMOUR ACTIVITY | 2018 |
|
RU2726195C2 |
| METHOD OF PRODUCING PENTACYCLO[7.5.0.0.0.0]TETRADECA-3,12-DIENE | 2013 |
|
RU2551283C1 |
| METHOD OF OBTAINING Si-CONTAINING BIS-(ENDO-BICYCLO[4.2.1]NONA-2,4,7-TRIENES) | 2013 |
|
RU2541792C1 |
| 0 |
|
SU172764A1 | |
| METHOD FOR COMBINED PRODUCTION OF 1-HYDROXYMETHYL-SUBSTITUTED BICYCLO[4_2_1]NONA-2,4,7-TRIENES EXHIBITING ANTINEOPLASTIC ACTIVITY | 2019 |
|
RU2735661C1 |
| METHOD FOR COMBINED PRODUCTION OF 1-METHYL-SUBSTITUTED BICYCLO[4_2_1]NONA-2,4,7-TRIENES EXHIBITING ANTITUMOUR ACTIVITY | 2019 |
|
RU2735663C1 |
