FIELD: medicine.
SUBSTANCE: the present innovation deals with new polypeptide of hepatitis C virus NS3/4A and its application in vaccine. This new polypeptide has got sequence SEQ ID NO: 17, a polynucleotide coding this polypeptide with sequence SEQ ID NO: 16, a recombinant vector of expression that contains this polynucleotide, a genetically constructed host cell that contains this recombinant vector, an antibody that interacts with polypeptide NS3/4A and immunogenic compositions that contain polypeptide NS3/4A and ribavirin, and, also, polynucleotide SEQ ID NO: 16 and ribavirin. The innovation enables to increase immunogenicity of new polypeptide NS3/4A.
EFFECT: higher efficiency.
14 cl, 15 ex, 15 tbl
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