FIELD: biotechnology.
SUBSTANCE: invention provides (a) isolated immunogenic PAA polypeptides; (b) recovered nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions containing an immunogenic polypeptide PAA or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to use of said polypeptides, nucleic acid molecules and compositions; and (e) a vaccine-based immunotherapy regimen which involve combined administration of the vaccine in a combination with an immune-effector cell enhancer.
EFFECT: presented are prostate-associated antigens and immunotherapeutic regimens based on vaccines.
28 cl, 43 dwg, 32 tbl, 20 ex
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