FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to aqueous autoclaving composition for parantheral administration useful in treatment of pathological heart conditions. Claimed composition contains methyl-3-[4-(2-hydroxy-3-isopropylamino)propoxy]-phenylpropionate hydrochloride (esmolol hydrochloride), buffer agent and osmotic controlling agent. Composition has pH between 4.5 and 5.5. Also disclosed is method for production of abovementioned esmolol hydrochloride composition including step of composition autoclaving in sealed container for time sufficient to sterilize the composition. After autoclaving composition is stable for at least 24 months.
EFFECT: composition of prolonged storage time.
11 cl, 3 ex
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