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(19)

(11)

2 093 520

(13)

(51)

IPC

(21) (22)

Application

94033267/04, 1994-09-12

(22)

Actual filing date

1994-09-12

(45)

Published

1997-10-20

(72)

Inventor

Evstigneeva R.P.Zheltukhina G.A.Nebol'Sin V.E.Ogrel' S.A.Rozhkova E.A.

(73)

Holder

Moskovskaja Gosudarstvennaja Akademija Tonkoj Khimicheskoj Tekhnologii Im.M.V.Lomonosova

BIOGENIC AMINE N-ACYL DERIVATIVES ARE MODULATORS OF LIPID PEROXIDE OXIDATION, AND METHOD OF PREPARATION THEREOF Russian patent published in 1997 - IPC

Abstract RU 2093520 C1

FIELD: bioorganic chemistry, biology and medicine. SUBSTANCE: biogenic amine acyl derivatives of general formula: X-CO-NH-Y in which X-CO is amino or fatty acid residue and NH-Y is residue of serotonine, tryptamine and hystamine which modulate lipid peroxide oxidation process. The present invention of preparing compounds of formula: XCONHY by anilation of biogenic amine amino group with pentafluorophenyl esters of N-substituted acids or fatty acid chlorides in organic solvent followed by cleaning by ion exchange chromatography, isoelectric deposition or repeated extraction from water and organic solvents. EFFECT: more efficient preparation method. 3 cl

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RU 2 093 520 C1

Authors

Evstigneeva R.P.

Zheltukhina G.A.

Nebol'Sin V.E.

Ogrel' S.A.

Rozhkova E.A.

Dates

1997-10-20—Published

1994-09-12—Filed