METHOD FOR INDIVIDUAL SENSITIVITY TO PREPARATIONS OF 5-AMINOSALYCILIC ACID (5-ASA) IN PATIENTS WITH ULCEROUS COLITIS Russian patent published in 2006 - IPC G01N33/50 

FIELD: medicine, gastroenterology.

SUBSTANCE: it is necessary to carry out a sample in vitro at detecting the synthesis of leukotriene B₄ (LTB₄) and thromboxin B₂ with polymorphonuclear leukocytes (PMNL) at injecting the preparation of 5-aminosalycilic acid into incubation medium and without it. In case of decreased LTB₄ and TB₂ synthesis at PMNL loading in vitro with salofalc being less than by 25% it is possible to expect decreased sensitivity to the preparation and, thus, decreased clinical effect in the form of prolonged terms for remission development and/or the onset of earlier relapse. At decreased synthesis of both metabolites of arachidonic acid under salofalc impact being more than by 25% it is possible to predict normal cell sensitivity to the preparation and - thus - short terms for re mission development and its prolonged keeping.

EFFECT: higher accuracy and efficiency of detection.

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