FIELD: organic chemistry, chemical technology, pharmacy.
SUBSTANCE: invention relates to a method for synthesis of 1-phenyl-2,3-dimethyl-4-iodopyrazolone-5 (iodoantipyrine) representing a medicinal preparation. Invention proposes a method for synthesis of iodoantipyrine by electrophilic iodination of antipyrine or antipyrine benzene sulfoacid under conditions of mechanical activation without solvent being both at the synthesis step and the isolation step. Using the proposed method provides preparing pharmacopoeia iodoantipyrine with the yield 57-96% depending on the parent substrate and an iodinating reagent, significant simplifying the process for its synthesis and the complete excluding an organic solvent.
EFFECT: improved method of synthesis.
4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 1-PHENYL-2,3-DIMETHYL-4-IODOPYRALOZONE-5 (IODOANTIPYRINE) SYNTHESIS METHOD | 2009 |
|
RU2401830C1 |
| METHOD OF PREPARING 1-PHENYL-2,3-DIMETHYL-4- IODOPYRAZOLONE-5-IODANTIPIRINE (VARIANTS) | 1996 |
|
RU2106344C1 |
| BI-NUCLEAR SULFUR-CONTAINING QUATERNARY AMMONIUM MOLYBDATES AS ADDITIVES TO LUBRICANTS | 2017 |
|
RU2742775C2 |
| METHOD OF SYNTHESIS OF 1-PHENYL-2,3-DIMETHYL-4-IODOPYRAZOLONE-5 (IODOANTIPYRINE) | 2000 |
|
RU2179551C1 |
| METHOD OF OBTAINING IODINE POLYSTYRENE | 2011 |
|
RU2467018C1 |
| METHOD OF IODINATION OF AROMATIC COMPOUNDS | 2010 |
|
RU2506254C2 |
| METHOD OF SYNTHESIS OF 2-SUBSTITUTED BENZO[B]THIOPHENE (VARIANTS), METHOD OF SYNTHESIS OF DERIVATIVES OF 2-PHENYL-3-AROYLBENZO[B]THIOPHENE (VARIANTS) AND DERIVATIVES OF BENZO[B]THIOPHENE | 1996 |
|
RU2147582C1 |
| METHOD OF PRODUCING IODINE DERIVATIVES OF AMINONAPHTHO- OR AMINOANTHRAQUINONES | 0 |
|
SU1182025A1 |
| ACID CORROSION INHIBITOR | 2001 |
|
RU2194092C1 |
