1-PHENYL-2,3-DIMETHYL-4-IODOPYRALOZONE-5 (IODOANTIPYRINE) SYNTHESIS METHOD Russian patent published in 2010 - IPC C07D231/22 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and synthesis of medicinal substances and can be widely used in synthesis of 1-phenyl-2,3-dimethyl-4-iodopyrazolone-5 (iodoantipyrine). The invention is primarily aimed at designing a method which cuts energy consumption, increases technological and environmental safety during production of pharmacopoeial iodoantipyrine with high output of not less than 95%. The method is based on oxidative iodination of antipyrine with an iodination mixture in the absence of an organic solvent and subsequent synthesis of pharmacopoeial iodoantipyrine. The method is characterised by successive steps for oxidative iodination and synthesis of pharmacopoeial iodoantipyrine in an aqueous medium in a single apparatus. The oxidative iodination process takes place at room temperature with concentration of components in the aqueous medium which ensures output of pharmacopoeial iodoantipyrine of not less than 95%.

EFFECT: simple technology of producing iodoantipyrine and apparatus used in the process, as well as high technological and environmental safety of the method.

7 cl, 5 ex