FIELD: medicine, oncology, pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to an antitumor agent. Anti-tumor liposomal preparation based on a mixture of flavolignans or their extracts prepared from spotted milk thistle (Silybium) fruits is made in liposomal formulation with particles size 100-500 nm. The preparation contains additionally vector component of peptide nature bound covalently to lipids of liposome envelope. As a vector component of peptide nature protein is used chosen from the group of representatives of family factors of epithelium growth, transforming growth factors, oncofetal proteins, endothelium growth factors and fibroblast growth factors, or the group active peptide fragments of protein said above. Above described preparation possesses the enhanced antitumor effect and its delivery rate to a tumor target-cell is increased. Invention can be used as an antitumor agent.
EFFECT: valuable medicinal property of preparation.
1 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION FOR THERAPY OF HEPATIC PATHOLOGIES AND ONCOLOGICAL DISEASES | 2008 |
|
RU2379046C1 |
| AGENT AND METHOD FOR TREATMENT AND PROPHYLAXIS OF ONCOLOGY DISEASES | 2005 |
|
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| COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF ONCOLOGICAL DISEASE | 2005 |
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| USE OF FLAVONOLIGNANS FOR INHIBITION OF EXCESSIVE AND PATHOLOGICAL PROLIFERATION OF VESSEL ENDOTHELIUM | 2005 |
|
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| PROPHYLAXIS COMPOSITION BASED ON PHENOLIC SUBSTANCES AND PHOSPHOLIPIDS | 2006 |
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|
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| BIOCOMPOSITION POSSESSING ANTITOXIC AND ANTI-ADAPTOSIS EFFECT, PROPHYLACTIC BIOLOGICAL SUPPLEMENT BASED ON THEREOF | 2005 |
|
RU2319498C2 |
| PREVENTIVE COMPOSITION BASED ON PHENOLIC SUBSTANCES IN LIPOSOME FORM | 2008 |
|
RU2372929C1 |
| SPOTTED MILK THISTLE-BASE BIOLOGICALLY ACTIVE SUPPLEMENT FOR DECREASING ALCOHOLIC DEPENDENCE | 2005 |
|
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| VECTOR POLYPEPTIDE ANALOG OF TRANSFORMING GROWTH FACTOR ALPHA (TGF) FRAGMENT, ITS ANTITUMOR CONJUGATE AND PHARMACEUTICAL COMPOSITION ON CONJUGATE BASE | 2004 |
|
RU2277930C1 |
