IMMUNOSTIMULATING OLIGODEOXYNUCLEOTIDES Russian patent published in 2007 - IPC A61K39/39 A61K31/7115 A61P37/04 

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to immunostimulating agents representing oligodeoxynucleotides of the formula (I): wherein any X represents oxygen (O) or sulfur (S) atom and wherein NMP represents deoxynucleoside monophosphate or monothiophosphate chosen from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxy-inosine-, deoxycytidine-, deoxyuridine-, deoxythymidine-, 2-methyldeoxyinosine-, 5-methyldeoxycytidine-, deoxypseudouridine-, deoxyribosepurine-, 2-aminodeoxyribosepurine-, 6-S-deoxyguanosine-, 2-dimethyldeoxyguanosine- or N-isopentenyldeoxyadenosine monophosphate or monothiophosphate; NUC represents 2'-deoxynucleoside chosen from the group consisting of deoxyadenosine-, deoxyguanosine-, deoxyinosine-, deoxycytidine-, deoxyuridine-, deoxythymidine-, 2-methyldeoxyinosine-, 5-methyldeoxycytidine-, deoxypseudouridine, -deoxyribosepurine-, 2-aminodeoxyribosepurine-, 6-S-deoxyguanosine-, 2-dimethyldeoxyguanosine- or N-isopentenyldeoxyadenosine; a and b are whole numbers from 0 to 100 under condition that a + b = 4-150; B and E are groups that are usual for 5'- and 3'-end of these molecules. Also, invention relates to immunostimulating pharmaceutical compositions containing indicated an immunostimulating agent or indicated an immunostimulating agent and antigen.

EFFECT: valuable medicinal property of oligodeoxynucleotides.

15 cl, 9 dwg, 6 ex