FIELD: organic chemistry, chemical-pharmaceutical industry, medicine, oncology.
SUBSTANCE: invention relates to a conjugate containing N-terminal fragment of hepatic growth factor (HGF/SF) that consists of "pin-like" domain and four cringle-like regions of α-chain and one polyethylene glycol group of the general molecular mass about 20-40 kDa and of the formula -CO-(CH2)x-(OCH2CH2)mOR or 
wherein -CO-group forms an amide bond with one of amino-group of N-terminal fragment of hepatic growth factor wherein X means 2 or 3; or y means 1-10; m has value from about 450 to about 950; or n and p in common have value from about 450 to 950; R means (C1-C6)-alkyl. The growth factor shows improved properties and it can be used as a therapeutic agent in treatment of cancer and metastasis of tumor cells.
EFFECT: valuable medicinal properties of conjugates.
7 cl, 1 tbl, 4 dwg, 9 ex
| Title |
Year |
Author |
Number |
| NOVEL PHARMACEUTICAL COMPOSITION |
2001 |
|
RU2281116C2 |
| CONJUGATES OF ERYTHROPOIETIN AND POLYETHYLENE GLYCOL, PHARMACEUTICAL COMPOSITIONS (VARIANTS), METHOD FOR PROPHYLACTIC AND/OR THERAPEUTIC TREATMENT OF DISTURBANCES AND METHOD FOR PREPARING CONJUGATE OR COMPOSITION |
2000 |
- Burg Jozef
- Khil'Ger Bernd
- Jozel' Khans-Peter
|
RU2232163C2 |
| NEW FUNCTIONAL, HIGH-PURITY STABLE CONJUGATE OF GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF) AND POLYETHYLENE GLYCOL WITH PROLONGED BIOLOGICAL ACTION, APPLICABLE FOR MEDICAL PURPOSES, AND BASED IMMUNOBIOLOGICAL AGENT |
2010 |
- Chernovskaja Tat'Jana Veniaminovna
- Rudenko Elena Georgievna
- Denisov Lev Aleksandrovich
- Morozova Elena Leonidovna
- Morozov Dmitrij Valentinovich
|
RU2446173C1 |
| NOVEL FUNCTIONALLY ACTIVE, HIGHLY PURE, STABLE CONJUGATE OF INTERFERON α WITH POLYETHYLENE GLYCOL, REPRESENTED BY ONE PEG- NH-IFN POSITIONAL ISOMER, WITH IMPROVED IMMUNOGENICITY, WITH PROLONGED BIOLOGICAL ACTION, SUITABLE FOR MEDICAL APPLICATION, AND IMMUNOLOGICAL AGENT BASED THEREON |
2010 |
- Chernovskaja Tat'Jana Veniaminovna
- Denisov Lev Aleksandrovich
- Morozov Dmitrij Valentinovich
- Rudenko Elena Georgievna
- Klenova Angelina Vsevolodovna
|
RU2447083C1 |
| PEG-CONTAINING POLYPEPTIDE T1249 |
2003 |
- Belon Paskal' Sebast'Jan
- Von' Dzhziob
|
RU2294938C2 |
| PEG-MODIFIED HUMAN INTERFERON β-1a MOLECULE WITH ANTIVIRAL, IMMUNOMODULATORY AND ANTIPROLIFERATIVE ACTIVITY, WITH IMPROVED STABILITY, REDUCED IMMUNOGENICITY, IMPROVED PHARMACOKINETIC AND PHARMACODYNAMIC PARAMETERS, SUITABLE FOR MEDICAL USE, AND IMMUNOBIOLOGICAL FORMULATION BASED THEREON |
2013 |
- Chernovskaja Tat'Jana Veniaminovna
- Efanov Jurij Georgievich
- Morozov Dmitrij Valentinovich
- Rudenko Elena Georgievna
- Korzhavin Dmitrij Valer'Evich
- Ustjugov Jakov Jur'Evich
- Ivanov Roman Alekseevich
|
RU2576372C2 |
| PEGYLATED POLYPEPTIDE T20 |
2003 |
- Belon Paskal' Sebast'Jan
- Von' Dzhziob
|
RU2296769C2 |
| PHARMACEUTICAL COMPOSITION AND METHOD OF TREATING GROWTH HORMONE-ASSOCIATED DISEASES IN HUMANS |
2014 |
- Rau Kharald
- Kindermann Zuzanne
- Lessmann Torben
- Rasmussen Grete Nerskov
- Kherzel Ulrikh
- Vegge Tomas
- Sprogee Kennet
|
RU2689336C2 |
| NEW VERSION OF EXENDIN OR ITS CONJUGATE |
2010 |
- Sjuj Majkl M.
- Van Junsjan
- Chzhan Inkhoj
- Lo Sjaosu
- Gun Njan'
- Chzhan Litsze
- Chzhou Sjantszjun'
|
RU2528734C2 |
| METHODS FOR AMINO GROUP PEGYLATION TO OBTAIN SITE-SPECIFIC CONJUGATES OF PROTEINS |
2016 |
- Rosendahl, Mary S.
- Mantripragada, Sankaram B.
|
RU2730848C2 |
