FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, more specifically to a conjugate of a version of exendin with a PEG molecule, and can be used in medicine. The above conjugate involves exendin with the amino acid sequence SEQ ID NO: 4 and one PEG molecule with molecular weight 21 kDa to 29 kDa conjugated with a cysteine residue in exendin. The invention also refers to a method for preparing an exendin conjugate, a pharmaceutical composition and a kit for lowering blood glucose providing using the exendin conjugate.
EFFECT: invention enables preparing the exendin conjugate with PEG with GLP-1 receptor agonist activity with maintaining the maximum effect on the stimulation of cAMP (Emax) production in PEGylation.
7 cl, 44 dwg, 5 tbl, 26 ex
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