FIELD: biotechnologies.
SUBSTANCE: invention relates to biotechnologies, especially to obtaining PEG conjugate and human interferon-β1a, and may be used in medicine. Attachment of a PEG linear molecule 20-40 kD to human interferon-β-1a produced a conjugate of formula (I): 
, wherein: n - an integer from 454 to 909; m - an integer ≥ 4; IFN is a natural or recombinant human interferon-β-1a. Compared to natural human interferonβ-1a, the conjugate of formula (I) provides a higher stability, reduced immunogenicity and improved pharmacokinetic and pharmacodynamic parameters.
EFFECT: conjugate may be used for treatment of various autoimmune, viral, and oncological diseases.
28 cl, 10 dwg, 9 tbl, 20 ex
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