FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, particularly to producing PEGylated granulocyte colony-stimulating factor (G-CSF), and is applicable in medicine. What is produced is a conjugate of G-CSF and monomethoxypolyethylene glycol attached to N-terminal methionine of the G-CSF of general formula: 
wherein n is integers within 681 to 1 000; m represents an integer ≥4; NαH-G-CSF represents the granulocyte colony-stimulating factor.
EFFECT: produced conjugate exhibits human G-CSF activity and prolonged biological action that makes it possible to use it in pharmaceutical compositions, and as a drug preparation for preventing and treating neutropenias.
17 cl, 10 dwg, 5 tbl, 21 ex
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