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2 297 241

(13)

(51)

IPC

A61K38/17(2006-01-01)

A61K39/385(2006-01-01)

C12N15/62(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2004133921/15, 2004-11-22

(24)

Start date

2004-11-22

(22)

Actual filing date

2004-11-22

(45)

Published

2007-04-20

(72)

Inventor

Kharchenko Vladimir PetrovichBozhenko Vladimir KonstantinovichKulinich Tat'Jana MikhajlovnaShishkin Aleksandr Mikhajlovich

(73)

Holder

Gosudarstvennoe Uchrezhdenie Rossijskij Nauchnyj Tsentr Rentgenoradiologii Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija

CHIMERIC PROTEIN FOR MALIGNANT LYMPHOMA TREATMENT Russian patent published in 2007 - IPC A61K38/17 A61K39/385 C12N15/62 A61P35/00

Abstract RU 2297241 C2

FIELD: medicine, oncology, peptides.

SUBSTANCE: invention relates to a chimeric protein used in treatment of malignant lymphomas. Invention proposes chimeric protein consisting of two peptides representing inhibitor of cyclin kinases as an active fragment p16INK4a with amino acid sequence 84-13 or 84-106 as a therapeutic agent and the second peptide VP22 with sequence 140-301 of virus herpes simplex as a transporting agent. Advantage of the invention involves the development of preparation of high effectiveness of penetration into cells and possessing cytostatic and cytotoxic effects.

EFFECT: valuable medicinal properties of chimeric protein.

1 dwg, 2 ex

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RU 2 297 241 C2

Authors

Kharchenko Vladimir Petrovich

Bozhenko Vladimir Konstantinovich

Kulinich Tat'Jana Mikhajlovna

Shishkin Aleksandr Mikhajlovich

Dates

2007-04-20—Published

2004-11-22—Filed