ISOQUINOLINE COMPOUNDS, INTERMEDIATE COMPOUNDS, METHODS FOR THEIR PREPARING AND USING Russian patent published in 2007 - IPC C07D217/24 C07D401/04 C07D401/06 C07D207/08 C07D207/12 C07D405/06 A61K31/4725 A61P9/00 

FIELD: organic chemistry, chemical technology, biochemistry, medicine.

SUBSTANCE: invention relates to novel isoquinoline compounds of the general formula (I): wherein R¹ represents hydrogen atom, halogen atom or alkyl; Y is absent or represents alkylene chain comprising from 1 to 8 carbon atoms wherein arbitrary carbon atom can comprise hydroxyl group as a substitute; R represents the following formula (II): wherein X represents -CH or nitrogen atom under condition that if Y absent in the formula (I) then X must represent -CH; W represents -CH or nitrogen atom under condition that if X represents -CH then W must represents nitrogen atom; s represents a whole number from 1 to 3; t represents a whole number from 1 to 3; if R³ represents hydrogen atom or alkyl then R² represents hydrogen atom, alkyl, hydroxyl group or hydroxyalkyl, and R^2' represents hydroxyl group or hydroxyalkyl, and if R³ represents hydroxyalkyl then R² and R^2' represent hydrogen atom. Also, invention relates to their optically active forms, pharmaceutically acceptable salts, aqueous adducts, hydrates and solvates. Compounds of the formula (I) elicit inhibitory effect on activity of poly-(ADP-ribose)-polymerase and can be used in prophylaxis of diseases associated with cerebral infarction.

EFFECT: valuable medicinal properties of compounds, improved method of synthesis.

40 cl, 4 tbl, 55 ex