HETEROCYCLIC COMPOUNDS Russian patent published in 2010 - IPC C07D401/14 C07D417/14 C07D409/14 C07D403/06 C07D403/14 C07C205/40 C07D207/08 C07D207/26 C07D207/277 A61K31/454 A61K31/4545 A61K31/541 A61K31/496 A61K31/497 A61K31/506 A61K31/4155 A61P3/04 A61P3/06 A61P3/10 A61P9/12 

Abstract RU 2383539 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula

or

or to their pharmaceutically acceptable salts, where ring A, R2, R3, R4 and X are as defined in the description. The disclosed compounds are useful as 11βHSD1 inhibitor. The invention also relates to a pharmaceutical composition, an agent for treating or preventing pathology related to glucocorticoids, a 11βHSD1 inhibitor containing the disclosed compound or its pharmaceutically acceptable salt, and use of the disclosed compounds.

EFFECT: compounds are highly effective.

40 cl, 48 tbl, 191 ex

Similar patents RU2383539C2

Title Year Author Number
3-ALKYLIDENHYDRAZINO-HETEROARYL COMPOUNDS AS ACTIVATORS OF THROMBOPROTEIN RECEPTOR 2004
  • Ovada Singo
  • Ivamoto Sunsuke
  • Janagikhara Kazufumi
  • Mijadzi Katsuaki
  • Nakamura Takanori
  • Isivata Norikhisa
  • Khirokava Jutaka
RU2358970C2
PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS 2001
  • Dehvis Robert
  • Bebbington Dehvid
  • Negtel Ronal'D
  • Vehnnamehjker Marion
  • Li Pehn
  • Forester Kornelija
  • Pirs Ehlbert
  • Kehj Dehvid
RU2340611C2
CARBOSTYRIL COMPOUND 2005
  • Kuroda Takesi
  • Jamauti Takakhito
  • Sinokhara Tomoiti
  • Osima Kunio
  • Kitadzima Tikharu
  • Nagao Khitosi
  • Fukusima Tae
  • Tomojasu Takakhiro
  • Isijama Khironobu
  • Okhta Kazukhide
  • Takano Masaaki
  • Sumida Takumi
RU2430920C2
OXYGEN-SUBSTITUTED DERIVATIVES OF 3-HETEROAROYLAMINOPROPIONIC ACIDS AND THEIR APPLICATION AS PHARMACEUTICAL SUBSTANCES 2011
  • Ruf Sven
  • Pernershtorfer Jozef
  • Sadovski Torsten
  • Khorstik Georg
  • Shrojder Kherman
  • Buning Kristian
  • Ol'Pp Tomas
  • Shajper Bodo
  • Virt Klaus
RU2561126C2
MACROCYCLIC HEPATITIS TYPE C VIRUS INHIBITORS 2006
  • Vekhling Khorst
  • Samuehl'Sson Bertil'
RU2419619C2
(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS 2012
  • Ortega-Munos Alberto
  • Fajf Mattyu Kolin Tor
  • Martinell-Pedemonte Mark
  • Estyarte-Martines Mariya-De-Los-Ankheles
  • Valls-Vidal Nuriya
  • Kurts Guido
  • Kastro-Palomino-Lariya Khulio-Sesar
RU2681211C2
HETEROCYCLIC COMPOUND 2019
  • Ono, Koji
  • Ito, Masahiro
  • Tanaka, Toshio
  • Asano, Moriteru
  • Hirayama, Takaharu
  • Fujimoto, Jun
  • Sakauchi, Nobuki
  • Hirata, Yasuhiro
  • Toita, Akinori
  • Morishita, Nao
  • Kokubo, Hironori
  • Imaeda, Yasuhiro
  • Maezaki, Hironobu
  • Cary, Douglas Robert
  • Mizojiri, Ryo
  • Cho, Nobuo
  • Banno, Hiroshi
  • Tokuhara, Hidekazu
  • Arikawa, Yasuyoshi
RU2815003C2
AMINO-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND USE THEREOF AS PHARMACEUTICAL AGENTS 2012
  • Ruf Sven
  • Sadovski Torsten
  • Khorstik Georg
  • Shrojder Kherman
  • Buning Kristian
  • Olpp Tomas
  • Virt Klaus
RU2605600C2
PYRAZOLE[1,5-a]PYRIMIDINE DERIVATIVE 2006
  • Moritani Jasunori
  • Sirai Kimikhiro
  • Oi Mariko
RU2390523C2
NOVEL COMPOUND HAVING PARP INHIBITORY ACTIVITY 2012
  • Khonda Takakhiro
  • Enomoto Khirosi
  • Kavasima Kendzi
  • Takaoka Sindzi
  • Fudzioka Yasutaka
  • Matsuda Mamoru
  • Okhasi Kodzi
  • Fudzita Yukie
  • Khirai Sin-Itiro
  • Kurasima Khiroaki
RU2606635C2

RU 2 383 539 C2

Authors

Jamamoto Khirosi

Okhe Jasukhiro

Goto Khirojuki

Kharada Kazukhito

Jata Sindzi

Nisiu Dzun

Kakutani Makoto

Fudzii Sunsuke

Asakhina Kota

Ito Takasi

Dates

2010-03-10Published

2006-06-08Filed