FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention describes novel derivatives of dihydroimidazo[5,1-a]-β-carboline of the general formula (I): 
wherein R1 = R3 = R4 mean hydrogen atom (H); R2 means hydrogen, halogen atom, (C1-C6)-alkyl, hydroxyl, (C1-C6)-alkoxyl; R5 means hydrogen atom or (C1-C6)-alkyl; R6 and R7 mean independently hydrogen atom or (C1-C6)-alkyl or phenyl with exception compounds of the general formula (I) wherein R1-R6 mean hydrogen atom, and R7 means group -CH or phenyl, and their isomers and additive salts with pharmaceutically acceptable acid also, and a method for their synthesis and pharmaceutical composition. Novel compounds possess soporific effect and can be used in producing a medicinal agent.
EFFECT: improved method of synthesis and preparing, valuable medicinal properties of compounds and pharmaceutical composition.
5 cl, 10 tbl, 25 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL PYRANE DERIVATIVES, THEREOF OBTAINING AND APPLICATION IN PERFUMERY | 2009 |
|
RU2577250C2 |
| NOVEL BICYCLIC DIOXANES, PRODUCTION AND USE THEREOF AS AROMATIC COMPOUNDS | 2010 |
|
RU2562973C2 |
| NOVEL PYRROLE COMPOUNDS, SYNTHESIS METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | 2014 |
|
RU2607788C2 |
| METHOD OF PRODUCING AMINOPHENOL COMPOUNDS | 2005 |
|
RU2376280C2 |
| PYRIDYLOXY DERIVATIVES EFFECTIVE AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) GAMMA ACTIVATOR/MODULATOR | 2010 |
|
RU2480463C1 |
| CONDENSED 4-OXOPYRIMIDINE DERIVATIVE | 2005 |
|
RU2358969C2 |
| NOVEL PHOSPHATE COMPOUNDS, SYNTHESIS METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | 2014 |
|
RU2617682C2 |
| CONDENSED TRICYCLIC DERIVATIVES FOR TREATING PSYCHOTIC DISORDERS | 2005 |
|
RU2409582C2 |
| DERIVATIVES OF PYRAZOLE AS MEDICINAL AGENTS FOR TREATMENT OF DISEASES THAT OCCUR AS RESULT OF DISFUNCTION OF NICOTINE RECEPTORS ALFA7 | 2004 |
|
RU2376290C2 |
| DERIVATIVES OF BETA-CARBOLINE POSSESSING EFFECT OF PHOSPHODIESTERASE INHIBITORS, PHARMACEUTICAL COMPOSITION (VARIANTS), METHOD FOR ITS PREPARING, METHOD FOR INHIBITION OF PHOSPHODIESTERASE EFFECT (VARIANTS) AND METHOD FOR INCREASING CGMP CONCENTRATION | 2001 |
|
RU2271358C2 |
