IMPROVED CHELATE CONJUGATES Russian patent published in 2007 - IPC C07K7/08 C07K14/745 A61K51/08 A61K47/48 A61K49/00 C07C251/36

Abstract RU 2298012 C2

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to an improved chelate conjugates of the formula: wherein each R¹, R² and R³ represents independently R group; Y represents -(A)_n-X-Z wherein X represents -NH-, -CO₂-, -N(C=O)-; Z represents a biological group for directed delivery that is chosen from 3-20-membered peptide, substrate for enzyme, enzyme inhibitor or synthetic compound binding with receptor; -(A)_n represent linker wherein each A represents independently -CR₂-, -NRCO-, -CONR-, -CR₂OCR₂ or polyalkylene glycol group; n represents a whole number from 2 to 10; each R group represents independently hydrogen atom (H) or (C₁-C₁₀)-alkyl, or two R groups in common with atoms to which they are added form (C₃-C₆)-carbocyclic saturated ring. Complexes with radioactive metals are useful as radioactive pharmaceutical preparation, especially, with ^99mTc.

EFFECT: valuable medicinal properties of conjugates.

30 cl, 3 tbl, 4 dwg, 30 ex

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RU 2 298 012 C2

Authors

Archer Kolin Mill

Uodsvort Garri Dzhon

Ehngell Torgrim

Dates

2007-04-27—Published

2002-07-10—Filed