IMPROVED CONJUGATES N4 OF CHELATING AGENTS Russian patent published in 2009 - IPC A61K51/04 A61K51/08 A61K103/10 C07F13/00 C07C211/22 C07D403/10 C07K7/04 C07K7/02 

Abstract RU 2360701 C2

FIELD: medicine.

SUBSTANCE: invention refers to chelating agents and their technetium complexes to be used as radiopharmaceuticals and characterised by formula I where X is -NR-, -CO2-, -CO-, -NR(C=S)-, -NR(C=O)-, -CONR- or Q; Y represents amino acid, -CH2-, -CH2OCH2-, -OCH2CH2O- or X; Z is an aggregation from peptides, their analogues, substrata, antagonists or enzyme inhibitors, receptor-bonding compounds, oligonucleotides, oligo-DNA- or oligo-RNA-fragments; n is a number 1 to 8; m is a number 0 to 30; R represents H, C1-4alkyl, C2-4alkoxyalkyl, C1-4hydroxyalkyl or C1-4fluoroalkyl; Q represents remains of succinimide , A is a pharmaceutically acceptable anion.

EFFECT: production of new chelating agents applicable for making the technetium complexes.

22 cl, 12 ex, 3 dwg, 2 tbl

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Authors

Stori Ehntoni Ehjmonn

Uodsvort Garri

Pauehll Najdzhel Ehntoni

Dunkanson Filip

Dates

2009-07-10Published

2005-07-19Filed