PREPARATION COMPRISING INHIBITOR OF HETEROTRIMERIC G PROTEINS SIGNAL TRANSDUCTION IN COMBINATION WITH OTHER CYTOSTATIC AGENT FOR THERAPEUTIC USING IN CANCER TREATMENT Russian patent published in 2007 - IPC A61K45/00 A61K31/4985 A61K31/5517 A61K31/4709 A61P35/00

Abstract RU 2298417 C2

FIELD: medicine, oncology, pharmacology, pharmacy.

SUBSTANCE: invention relates to a preparation used in the simultaneous, separate or time-distributed therapeutic using in cancer treatment. The preparation comprises inhibitor of signals transduction of heterotrimeric G proteins chosen from 7-(2-amino-1-oxo-3-thiopropyl)-8-(cyclohexylmethyl)-2-methylphenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine, 7-(2-amino-1-oxo-3-thiopropyl)-8-(cyclohexylmethyl)-2-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine and at least one additional cytostatic agent also. Proposed preparations possess the enhanced effectiveness.

EFFECT: enhanced and valuable medicinal properties of preparation.

6 cl, 5 tbl, 1 ex

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RU 2 298 417 C2

Authors

Prevo Greguar

Lonsham Mari-Odil'

Gordon Tomas

Morgan Barri

Dates

2007-05-10—Published

2000-11-08—Filed