CONDENSED HETEROCYCLIC SUCCINAMIDE COMPOUNDS Russian patent published in 2007 - IPC C07D491/08 C07D495/08 C07D471/08 A61K31/40 A61K31/439 A61P35/00 

FIELD: organic chemistry, medicine, oncology.

SUBSTANCE: invention relates to condensed heterocyclic succinamide compounds of the formula (I): , their pharmaceutically acceptable salts, solvates or isomers wherein G represents mono- or polycyclic aryl or heterocyclic group substituted possibly at one or more positions; L represents a bond, -(CR⁷R^7')_n (wherein n = 1; R⁷ and R^7' represents independently hydrogen atom (H), alkyl or substituted alkyl) or -CH₂-NH-; Z₁ represents oxygen atom (O); Z₂ represents O; A₁ and A₂ represent -CR⁷ or in common with R⁷ from group W is a heterocyclic ring wherein oxygen represents a heteroatom; Y represents -O-, -SO-, -N(V²)-, -CH₂-N(V²)-, -CO-N-(alkyl)-, -CH₂-S-, -CH₂-SO₂-; V² represents hydrogen atom, alkyl, arylalkyl, -CO-alkyl, -CO-O-aryl, -CO-O-arylalkyl; W represents -CR⁷R^7'-CR⁷R^7'-, -CR⁷R^7'-C=O, -NR⁹-, -CR⁷R^7'-, -N=CR⁸-, -N=N, -NR⁹-NR^9'-, cycloalkyl or substituted cycloalkyl, cycloalkenyl or substituted cycloalkenyl, heterocyclo- or substituted heterocyclo-group, aryl or substituted aryl wherein if W doesn't mean -NR⁹-CR⁷R^7'-, -N=CR⁸-, -N=N, -NR⁹-NR^9'- or heterocyclo- or substituted heterocyclo-group then Y must mean -O-, -CH₂-S-, -SO-, -CH₂-SO₂-, -N-(V²)- or -CH₂-N-(V²)-; Q₁ and Q₂ represent hydrogen atom (H). Also, invention describes a method for synthesis of intermediate compounds in synthesis of compounds of the formula (I), using the latter for preparing agents modeling function of the nuclear hormone receptors. Compounds of the formula (I) can be used in treatment of prostate cancer.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds.

8 cl, 11 tbl, 463 ex