FIELD: chemistry.
SUBSTANCE: invention relates to novel methyl, chloro and nitro-derivatives of N-{3,5-dioxo-4-azatetracyclo [5.3.2.02,6.08,10]dodec-11-en-4-yl}-2-hydroxybenzamide of formula I:
la R=5-Cl, lb R=4-Me, Ic R=5-Me, Id R=5-NO2, which exhibit antiviral activity with respect to different types of orthopoxviruses which are pathogenic for humans and animals. The compounds are obtained through reaction of hydrazides of derivatives of ortho-hydroxybenzoic acid with 4,4a,5,5a,6,6a-hexahydro-4,6-etheno-1H-cycloprop/f/isobenzofuran-1,3(3aH)-dione in acetic acid while boiling for 8-12 hours. Output is equal to 91-98%.
EFFECT: obtaining novel compounds.
1 dwg, 2 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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