PHENYLTETRAHYDROISOQUINOLINE COMPOUND, SUBSTITUTED WITH HETEROARYL Russian patent published in 2019 - IPC C07D401/10 C07D401/14 C07D403/14 C07D405/10 C07D413/10 C07D413/14 C07D417/10 A61K31/4725 A61K31/501 A61K31/506 A61P1/10 A61P7/00 A61P9/12 A61P13/12 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a compound of formula [1] or a pharmaceutically acceptable salt thereof, where A is a structure represented by the following formula [2], where R¹¹ and R¹² are identical or different and each represents a hydrogen atom or a halogen atom; R² is a hydrogen atom or C_1-6 alkyl; ring E is pyrrole, furan, pyrazole, imidazole, isoxazole, oxazole, isothiazole, triazole, oxadiazole, tetrazole, pyridine, pyridazine, pyrimidine or pyrazine; R³¹ and R³² are identical or different and each represents a hydrogen atom, cyano, C_1-6 alkyl, C_1-6 alkoxy or mono-C_1-6 alkylamino, and W is a single bond, formula -NH-, formula -O- or formula -CONH-, and Y is a hydrogen atom or any structure of following formulas [3'], where Z¹, Z³, L², L²', L²"and L²''' have the values given in claim 1; each A', A' and A''' is a structure identical to the structure presented by A. Invention also relates to a medicinal agent, an NHE3 inhibitor and a preventive and therapeutic agent based on a compound formula [1].

EFFECT: technical result: obtaining a novel heterocyclic compound having inhibitory action on Na⁺/H⁺ exchanger 3 (NHE3).

21 cl, 14 tbl, 113 ex