3-PHENYL-3,7-DIAZABICYCLO[3,3,1]NONANE COMPOUNDS, METHOD FOR THEIR PREPARING AND MEDICINAL AGENTS CONTAINING THESE COMPOUNDS Russian patent published in 2007 - IPC C07D471/08 C07D471/10 A61K31/4375 A61P9/06

Abstract RU 2299210 C2

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to novel 3-phenyl-3,7-diazabicyclo[3,3,1]nonane compounds of the formula (I): wherein R¹ means (C₁-C₆)-alkyl, (C₄-C₇)-cycloalkyl; R² means (lower)-alkyl; R³ means (lower)-alkyl, or R² and R³ form in common (C₃-C₆)-alkylene chain; R⁴ means phenyl monosubstituted at ortho- or para-position with nitro-, cyano-group or (lower)-alkanoyl, or disubstituted at ortho- and para-position with nitro-group, and their physiologically acceptable acid-additive salts. Compounds of the formula (I) possess anti-arrhythmic activity and therefore they can be used in pharmaceutical composition used in treatment and/or prophylaxis of cardiac rhythm disorders. Also, invention describes a method for synthesis of these compounds.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

8 cl, 6 tbl, 2 ex

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RU 2 299 210 C2

Authors

Shen Uve

Messinger Jozef

Brjukner Rajnkhard

Tsigler Diter

Dates

2007-05-20—Published

2002-06-27—Filed