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2 301 807

(13)

(51)

IPC

C07D409/06(2006-01-01)

C07D407/06(2006-01-01)

A61K31/496(2006-01-01)

(21) (22)

Application

2002124199/04, 2002-09-12

(24)

Start date

2002-09-12

(22)

Actual filing date

2002-09-12

(45)

Published

2007-06-27

(72)

Inventor

Dan'El' JasseranUl'F ProjshoffJokhen Antel'Zamuehl' DavidKhol'Ger ZannRajnkhard BrjuknerDania RajkheKristian Ehkaut

(73)

Holder

Zol'Vaj Farmas'Jutiklz Gmbkh

1-[1-(HETERO)ARYL-1-PERHYDROXYALKYLMETHYL]PIPERAZINE COMPOUNDS, METHODS FOR THEIR PREPARING AND MEDICINAL AGENTS CONTAINING THEREOF Russian patent published in 2007 - IPC C07D409/06 C07D407/06 A61K31/496

Abstract RU 2301807 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to 1-[1-(hetero)aryl-1-perhydroxyalkylmethyl]piperazine compounds of the general formula (I): wherein A means naphthyl, phenyl optionally substituted with methoxy-group, heteroaryl chosen from group comprising thienyl, furyl, indolyl or (C₃-C₆)-alkenyl optionally substituted with phenyl; Z means subgroup of the general formula: wherein k, l, m and n mean 0 or 1; R⁶ and R⁷ mean halogen atom, and to their physiologically acceptable acid-additive salt. Compounds possess antagonistic activity with respect to tachykinin receptors and can be used in treatment of digestive tract functional and inflammatory disorders. Also, invention describes a method for synthesis of proposed compounds and intermediate substances used in realization of this method, and medicinal agents containing indicated compounds.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds.

9 cl, 3 tbl, 40 ex

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RU 2 301 807 C2

Authors

Dan'El' Jasseran

Ul'F Projshoff

Jokhen Antel'

Zamuehl' David

Khol'Ger Zann

Rajnkhard Brjukner

Dania Rajkhe

Kristian Ehkaut

Dates

2007-06-27—Published

2002-09-12—Filed