CYCLIC IMINOPYRIMIDINE DERIVATIVES AS KINASE INHIBITORS Russian patent published in 2023 - IPC C07D487/14 C07D487/04 C07D471/14 A61K35/04 A61K31/519 A61P25/28 A61P35/00 

FIELD: heteroaromatic compounds.

SUBSTANCE: following is proposed: a compound of formula (I) or its stereoisomer, where: each X₁ and X₃ independently represents CR^a; X₂ is N or CR^a; each Y₁ and Y₃ is independently N or CR^b; Y₂ is CR^b; Z₁ is O or NR^c; Z₂ is a bond or NR^f; m is 0, 1 or 2; n is 1, 2 or 3; R₁ is C₁-C₆ alkyl or C₁-C₆ alkyl substituted with -NR^hRⁱ; R₂ is selected from the group consisting of hydrogen, halogen, CN, NO₂ and CF₃; R₃ is C₁-C₆ alkyl; C₁-C₆ alkyl substituted with halogen; C₁-C₆ alkyl substituted with OH; heterocyclyl containing from 1 to 10 ring carbon atoms and from 1 to 4 ring heteroatoms selected from the group consisting of nitrogen, sulfur and oxygen; heterocylyl substituted with halogen, wherein the heterocyclyl contains from 1 to 10 ring carbon atoms and from 1 to 4 ring heteroatoms selected from the group consisting of nitrogen, sulfur and oxygen; aryl substituted with halogen, where aryl contains from 6 to 14 ring carbon atoms; and heteroaryl containing from 1 to 10 ring carbon atoms and at least one ring heteroatom selected from the group consisting of nitrogen, sulfur and oxygen; R₄ is hydrogen or C₁-C₆ alkyl; R^a is H; R^b is H, halogen, -NH₂ or -NO₂; R^c represents H or C₁-C₆ alkyl; and each of R^f, R^h and Rⁱ independently represents C₁-C₆ alkyl. Also specific compounds and the use of a compound of formula (I) for the treatment of diseases susceptible to inhibition of B-Raf V600E kinase and inhibition of B-Raf V600E kinase activity in a cell are provided.

EFFECT: obtaining heterocyclic compounds with inhibitory activity against B-Raf V600E kinase.

48 cl, 7 tbl, 53 ex