PEPTIDE POSSESSING IMMUNOGEROPROTECTIVE EFFECT, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR ITS USING Russian patent published in 2007 - IPC A61K38/06 A61P37/02 

Abstract RU 2301074 C1

FIELD: medicine, peptides, pharmacy.

SUBSTANCE: invention relates to medicinal agents used in prophylaxis and correction of age disorders in cellular and humoral immunity. Invention proposes a pharmaceutical composition possessing immunogeroprotective effect and containing the effective amount of peptide glutamyl-aspartyl-proline of the general formula: H-Glu-Asp-Pro-OH of the sequence 1 [SEQ ID NO:1] as an active component. Invention proposes peptide glutamyl-aspartyl-proline of the general formula: H-Glu-Asp-Pro-OH of the sequence 1 [SEQ ID NO:1] that possesses immunogeroprotective effect. Also, invention proposes a method for prophylaxis and correction of age disorders in cellular and humoral immunity by stimulation of processes of proliferation and differentiation of lymphocytes. Method involves administration in a patient a pharmaceutical composition containing peptide glutamyl-aspartyl-proline of the formula: H-Glu-Asp-Pro-OH of the sequence 1 [SEQ ID NO:1] in the dose 0.01-100 mcg/kg of body mass as an active component at least once per a day for period necessary for providing the therapeutic effect. Invention provides creature of peptide possessing immunogeroprotective effect and pharmaceutical composition containing this peptide as an active component that stimulates processes of proliferation and differentiation of lymphocytes based on recovery in synthesis of tissue-specific proteins, normalization of metabolic and molecular-genetic indices in age disorders of cellular and humoral immunity. Proposed peptide can be used as an agent possessing immunogeroprotective effect.

EFFECT: valuable medicinal and biological properties of peptide.

6 cl, 4 tbl, 2 dwg, 8 ex

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RU 2 301 074 C1

Authors

Khavinson Vladimir Khatskelevich

Grigor'Ev Evgenij Iosifovich

Malinin Vladimir Viktorovich

Ryzhak Galina Anatol'Evna

Dates

2007-06-20Published

2006-05-30Filed