KALLIKREIN SELECTIVE DIPEPTIDE INHIBITORS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHOD OF TREATMENT Russian patent published in 2007 - IPC C07D211/58 C07K5/06 A61K31/4468 A61P29/00

Abstract RU 2301225 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel 4-(dipeptidylamino)-piperidine-1-carboxamidines of the general formula (1): or their optical isomers or pharmaceutical acceptable salts wherein R¹ is chosen from hydrogen atom (H), lower alkyl, R⁴-CO wherein R⁴ means -OCCH₂, R⁵-OCO wherein R means -SO₂; R² is chosen from lower alkyl, cycloalkyl, (C₅-C₁₂)-cycloalkylalkyl, phenylalkyl and others; R³ is chosen from H, -OH and group O-lower alkyl; R⁴ is chosen from H, lower alkyl and phenyl; R⁵ is chosen from lower alkyl, phenyl and benzyl. Proposed compounds are inhibitors of kallikrein and can be used in treatment of intestine inflammatory disease, arthritis, septic shock, hypotension or cancer.

EFFECT: valuable medicinal properties of compounds.

12 cl, 2 tbl, 60 ex

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RU 2 301 225 C2

Authors

Ivanz Dejvid Majkl

Dates

2007-06-20—Published

2003-03-04—Filed