FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel 4-(dipeptidylamino)-piperidine-1-carboxamidines of the general formula (1): 
or their optical isomers or pharmaceutical acceptable salts wherein R1 is chosen from hydrogen atom (H), lower alkyl, R4-CO wherein R4 means -OCCH2, R5-OCO wherein R means -SO2; R2 is chosen from lower alkyl, cycloalkyl, (C5-C12)-cycloalkylalkyl, phenylalkyl and others; R3 is chosen from H, -OH and group O-lower alkyl; R4 is chosen from H, lower alkyl and phenyl; R5 is chosen from lower alkyl, phenyl and benzyl. Proposed compounds are inhibitors of kallikrein and can be used in treatment of intestine inflammatory disease, arthritis, septic shock, hypotension or cancer.
EFFECT: valuable medicinal properties of compounds.
12 cl, 2 tbl, 60 ex
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