FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention describes derivatives of substituted N-phenyl-2-hydroxy-2-methyl-3,3,3-trifluoropropaneamide of the formula (I): 
wherein R represents methyl or mesyl, or its salt. Also, invention describes methods for synthesis of these compounds, pharmaceutical compositions containing thereof and their using for increasing activity of PDH in warm-blooded animal. Proposed compounds are useful in treatment of diabetes mellitus in warm-blooded animals.
EFFECT: valuable medicinal properties of compounds, improved methods for synthesis.
10 cl, 4 ex
| Title |
Year |
Author |
Number |
| SUBSTITUTED DERIVATIVES OF N-PHENYL-2-HYDROXY-2-METHYL-3,3,3-TRIFLUOROPROPANEAMIDE ENHANCING ACTIVITY OF PYRUVATE DEHYDROGENASE |
2000 |
- Batlin Rodzher Dzhon
- Pis Dzhanet Ehlizabet
- Blok Majkl Khovard
- Novak Torsten
- Barrous Dzheremi Nikolas
|
RU2255085C2 |
| APPLYING COMPOUNDS FOR ENHANCING ACTIVITY OF PYRUVATE DEHYDROGENASE |
1999 |
- Batlin Rodzher Dzhon
- Novak Torsten
- Barrouz Dzheremi Nikolas
- Blok Majkl Khauard
|
RU2242224C2 |
| BENZOTHIADIAZEPINE DERIVATIVES AND METHOD FOR PRODUCTION THEREOF (VARIANTS) |
2002 |
- Starke Ingemar
- Dal'Strum Mikaehl' Ul'F Jukhan
- Blumberg David
- Alenfal'K Suzanne
- Sharet Ture
- Lemurell' Malin
|
RU2305681C2 |
| DERIVATIVES OF SUBSTITUTED PHENYLPROPIONIC ACID AS AGONISTS OF HUMAN ALPHA-RECEPTORS ACTIVATED BY PEROXISOME PROLIFERATOR (PPARα), METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHODS FOR TREATMENT OF DYSLIPIDEMIA IN DIABETES MELLITUS TYPE 2 |
2002 |
- Al'Stermark Lindstedt Ehva-Lotte
- Ol'Sson Anna Kristina
- Li Lanna
|
RU2303031C2 |
| DERIVATIVES OF SUBSTITUTED PHENYLPROPIONIC ACID AS AGONISTS OF HUMAN ALPHA-RECEPTOR (PPARα) ACTIVATED BY PEROXISOME PROLIFERATORS, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHODS FOR DYSLIPIDEMIA TREATMENT AND TYPE 2 DIABETES MELLITUS |
2002 |
- Al'Stermark Lindstedt Ehva-Lotte
- Ol'Sson Anna Kristina
- Li Lanna
|
RU2300517C2 |
| IMIDAQZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR INHIBITION OF CELL PROLIFERATION, METHOD FOR THEIR PREPARING (VARIANTS), USING, PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING |
2001 |
- Bro Glorija Ann
- N'Jukom Nikolas Dzhon
- Tomas Ehndrju Piter
|
RU2284327C2 |
| SYNTHESIS AND USE OF TETRAHYDROPYROLLO[3,2-c]PYRIDIN-4-ONE DERIVATIVES TO TREAT OBESITY, PSYCHIATRIC AND NEUROLOGICAL DISORDERS |
2006 |
|
RU2415856C2 |
| PHARMACEUTICAL DEPOT, CONTAINING N-{ 5-[(CYCLOPROPYLAMINO)CARBONYL]-2-METHYLPHENYL} -3-FLUORO-4-([PYRIDIN-2-YLMETHOXY)BENZAMIDE |
2009 |
- Behjtmehn Nikola Frehnsis
- Makfaul Filip Aleksander
- Nehsh Ajan Alun
|
RU2538702C2 |
| N-(2-BENZYL)-2-PHENYLBUTANAMIDES AS ANDROGEN RECEPTOR MODULATORS |
2005 |
- Khanni Barbara
- Kim Juntae
- Krout Majkl R.
- Mejssner Robert S.
- Mitchell Khelen Dzh.
- Masselman Dzheffri
- Perkins Dzhejms Dzh.
- Vang Dziabing
|
RU2378255C2 |
| DERIVATIVES OF PYRIMIDINE, METHOD FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITIONS (VARIANTS) AND INHIBITION METHOD |
2001 |
- Tomas Ehndrju Piter
- N'Jukom Nikolas Dzhon
- Khiton Dehvid Uill'Jam
|
RU2299201C2 |
