DERIVATIVES OF SUBSTITUTED PHENYLPROPIONIC ACID AS AGONISTS OF HUMAN ALPHA-RECEPTOR (PPARα) ACTIVATED BY PEROXISOME PROLIFERATORS, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHODS FOR DYSLIPIDEMIA TREATMENT AND TYPE 2 DIABETES MELLITUS Russian patent published in 2007 - IPC C07C235/20 C07C69/712 A61K31/165 A61P3/00 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to S-enantiomers of compound of the formula (I): wherein R¹ represents 2,4-difluorophenyl or cyclohexyl, and its pharmaceutically acceptable salts and solvates. S-enantiomers of compound of the formula (I) are chosen from (2S)-3-(4-{2-[(cyclohexylmethyl)(heptyl)amino]-2-oxoethoxy}phenyl)-2-ethoxypropionic acid and (2S)-3-3-(4-{2-[(2,4-difluorobenzyl)(heptyl)amino]-2-oxoethoxy}phenyl)-2-ethoxypropionic acid and their pharmaceutically acceptable salts and solvates. Invention relates to pharmaceutical preparation possessing agonistic activity with respect to PPARα (activated by peroxisome proliferators of human alpha-receptors) and comprising compound of the formula (I) in mixture with pharmaceutically acceptable adjuvants, excipients and/or carriers. S-enantiomer of compound of the formula (I) is used in producing a medicinal agent used in treatment of lipid disorders (dyslipidemia) associated or not associated with resistance to insulin. Also, this invention is used in treatment or prophylaxis of lipid disorders (dyslipidemia) associated or not associated with resistance to insulin and diabetes mellitus of type 2. Invention proposes derivatives of substituted phenylpropionic acid as agonists of human alpha-receptors activated by peroxisome proliferators (PPARα).

EFFECT: valuable medicinal properties of compounds, improved method of treatment.

12 cl, 2 ex