FIELD: organic chemistry, chemical technology, microbiology.
SUBSTANCE: invention relates to novel 2,2,5,5-tetrabromo-1,6-di-(4'-methylphenyl)-1,3,4,6-hexanetetraone of the formula (I): 
that possesses antibacterial activity. Compound of the formula (I) is synthesized by interaction of 3,4-dihydroxy-1.6-di-(4'-methylphenyl)-2,4-hexadiene-1,6-dione with bromine in chloroform medium. Compound of the formula (I) possesses antibacterial activity with respect to Staphylococcus aureus with MAC (maximum allowable concentration) value = 0.0075-0.06 mcg/ml and to colon bacillus with MAC value = 0.12-0.32 mcg/ml and with the acute toxicity value LD50 = 2960 mg/ml.
EFFECT: valuable activity of compound.
1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| N-SUBSTITUTED AMIDES OF 2-HYDROXY-4-OXO-4-(4-CHLOROPHENYL) 2-BUTENOIC ACID, EXHIBITING ANTIMICROBIAL ACTIVITY | 2009 |
|
RU2429225C2 |
| BENZYLAMMONIUM SALT OF 4-ETHOXYCARBONYL-5-OXO-2-(2-OXO-2-PHENYLETHYLIDENE)-2,5-DIHYDRO-1H-PYRROLE-3-OLATE, SHOWING ANTIMICROBIAL ACTIVITY | 2022 |
|
RU2781135C1 |
| SUCCINATE OF N-(2,4,6-TRIMETHYLPHENYL)AMIDE 2-(BETA-N,N-DIETHYLAMINO ETHYLAMINO)-4-OXO-4-(4-METHYYLPHENYL)-2-BUTENOIC ACID | 2009 |
|
RU2428412C2 |
| 6-NITRO-2-IMINOCOUMARIN 3-CARBOXYLIC ACID 4-TOLUIDIDE SILVER SALT ELICITING ANTIBACTERIAL ACTIVITY | 2003 |
|
RU2247119C1 |
| 2-(2,4-DICHLORANILINO)-1,4-BIS(4-METHYLPHENYL)-2-BUTEN-1,4-DION, POSSESSING ANTIMICROBIAL ACTIVITY | 2008 |
|
RU2396249C2 |
| METHOD OF SYNTHESIS OF 1,6-DIARYL-3,4-DIHYDROXY-2,4-HEXADIENE-1,6-DIONES | 1990 |
|
SU1767835A1 |
| APPLICATION OF 5-BROMO-3,4-DIHYDROXY-2-CARBAMOYL-6-OXO-6-PHENYL-2,4-HEXADIENIC ACID ETHYL ESTER AS AGENT ELICITING ANTIBACTERIAL ACTIVITY | 2002 |
|
RU2229473C2 |
| PROCESS FOR PREPARING 1,6-DIARYL-1,3,4,6-HEXANETETRAONES | 0 |
|
SU1051059A1 |
| N-(2-BENZOTHIAZOLYL)AMIDE 2-HYDROXY-4-OXO-4-(4-CHLOROPHENYL)-2-BUTENOIC ACID HAVING ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY | 2008 |
|
RU2396262C2 |
| IZOPROPYLAMIDE OF 2-(BETA-2,4-DINITROPHENYLHYDRAZINO)CINHONINIC ACID, DEMONSTRATING ANTIMICROBIAL ACTIVITY | 2008 |
|
RU2364590C1 |
