FIELD: chemistry.
SUBSTANCE: invention relates to novel substituted pyrazine pyrimidinones of general formula I or racemic mixtures, individual optical isomers and pharmaceutically acceptable salts thereof, which possess properties of TRPA1 channel blockers. In formula I, R1=H, (C1-C5) alkyl; R2=H, (C1-C5) alkyl; R3=H, (C1-C5) alkyl; R4=H, (C1-C7) alkyl, (C1-C7) alkyl, substituted with (C3-C7) cycloalkyl, (C3-C7) cycloalkyl; R5=H, (C1-C5) alkyl, heterocyclyl, where heterocyclyl denotes a saturated monocyclic system including 4 to 6 carbon atoms, in which one carbon atom is substituted by a heteroatom, such as nitrogen.
EFFECT: invention also relates to a method of producing compounds of general formula I, an active component, a pharmaceutical composition and a method of anaesthesia using said compounds.
6 cl, 3 tbl, 1 dwg, 3 ex
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