Show metadata Hide metadata

(19)

(11)

2 574 392

(13)

(51)

IPC

C07K5/97(2006-01-01)

C07K1/02(2006-01-01)

(21) (22)

Application

2014146802/04, 2014-11-21

(24)

Start date

2014-11-21

(22)

Actual filing date

2014-11-21

(45)

Published

2016-02-10

(72)

Inventor

Nazarenko Anna BorisovnaBalaev Aleksandr NikolaevichOkhmanovich Kirill Anatol'EvichFedorov Vladimir Egorovich

(73)

Holder

Diamondzlite Limited

METHOD FOR OBTAINING TREPEPTIDE OF GENERAL FORMULA (I) HPyr-His-TrpOH, APPLIED AS INTERMEDIATE COMPOUND (1-3 FRAGMENT) IN SYNTHESIS OF SYNTHETIC AGONISTS OF GONADOTROPIN-RELEASING-HORMONE (LH-RH), BY METHOD OF LIQUID-PHASE PEPTIDE SYNTHESIS WITHOUT PLACING AND REMOVAL OF PROTECTIVE GROUPS Russian patent published in 2016 - IPC C07K5/97 C07K1/02

Abstract RU 2574392 C1

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining HPyr-His-TrpOH applied as main semi-product (1-3 fragment) in synthesis of synthetic antagonists of gonadotropine-releasing-hormone, LH-RH. Tripeptide (I) is obtained by method of liquid-phase peptide synthesis without application of stages of placement and removal of protective groups.

EFFECT: method makes it possible to reduce quantity of synthesis stages, is more economically effective due to absence of placement and removal of protective groups stages and makes it possible to obtain tripeptide with high purity.

1 ex

Similar patents RU2574392C1

Title	Year	Author	Number
METHOD FOR PRODUCING TRIPEPTIDE DIACETATE	2014	Nazarenko Anna Borisovna Balaev Aleksandr Nikolaevich Okhmanovich Kirill Anatol'Evich Fedorov Vladimir Egorovich Osipov Vasilij Nikolaevich	RU2551276C1
METHOD FOR SYNTHESIS NONAPEPTIDE ETHYLAMIDE AND INTEMEDIATE COMPOUNDS FOR SYNTHESIS THEREOF	2010	Nazarenko Anna Borisovna Fedorov Vladimir Egorovich	RU2444525C2
METHOD FOR PREPARING ADRENOCORTICOTROPIC HORMONE (ACTH) ANALOGS, SEQUENCE (4-10), POSSESSING NEUROTROPIC ACTIVITY AND TETRAPEPTIDE FOR ITS PREPARING	2006	Az'Muko Andrej Andreevich Baldin Mikhail Ivanovich Bespalova Zhanna Dmitrievna Molokoedov Aleksandr Sergeevich Nevzorova Nadezhda Vladimirovna Sidorova Marija Vladimirovna Ovchinnikov Mikhail Vladimirovich Frid Dmitrij Aleksandrovich	RU2315057C2
METHOD FOR TRIPEPTIDE PRODUCTION	2006	Az'Muko Andrej Andreevich Bespalova Zhanna Dmitrievna Molokoedov Aleksandr Sergeevich Ovchinnikov Mikhail Vladimirovich Pal'Keeva Marina Evgen'Evna Sidorova Marija Vladimirovna	RU2303602C2
METHOD FOR ACCELERATED PEPTIDE SYNTHESIS IN SOLUTION	2002	Ehggen Ivo Fransi Ten Kortenar Paulus Bernardus Vil'Khel'Mus Khasnot Kornelis Al'Bert Grjuson	RU2237673C2
TRIPEPTIDE HAVING NEUROPSYCHOTROPIC ACTIVITY	2023	Deeva Olga Alekseevna Mokrov Grigorij Vladimirovich Pantileev Andrej Sergeevich Povarnina Polina Yurevna Antipova Tatyana Alekseevna Gudasheva Tatyana Aleksandrovna Dorofeev Vladimir Lvovich	RU2823022C1
FODDER ADDITIVES REPRESENTED BY DIPEPTIDES	2010	Kristof Kobler Tomas Khojssner Katja Kel'M Kristof Vekbekker	RU2536467C2
METHOD OF OBTAINING DODECAPEPTIDE AND TRIPEPTIDE FOR ITS REALISATION	2007	Chazov Evgenij Ivanovich Bespalova Zhanna Dmitrievna Az'Muko Andrej Andreevich Sidorova Marija Vladimirovna Molokoedov Aleksandr Sergeevich Krasnikova Tat'Jana Leonidovna Aref'Eva Tat'Jana Igorevna Kukhtina Nadezhda Borisovna	RU2340626C1
TSPO DIPEPTIDE LIGANDS HAVING NEUROPSYCHOTROPIC ACTIVITY	2018	Seredenin Sergej Borisovich Deeva Olga Alekseevna Gudasheva Tatyana Aleksandrovna Yarkova Milada Alnordovna Povarnina Polina Yurevna Durnev Andrej Dmitrievich	RU2756772C2
WAY OF BUSERELIN PRODUCTION AND INTERMEDIATE COMPOUNDS FOR ITS PRODUCTION	2010	Nazarenko Anna Borisovna Fedorov Vladimir Egorovich	RU2442791C1

RU 2 574 392 C1

Authors

Nazarenko Anna Borisovna

Balaev Aleksandr Nikolaevich

Okhmanovich Kirill Anatol'Evich

Fedorov Vladimir Egorovich

Dates

2016-02-10—Published

2014-11-21—Filed