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2 574 392

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(51)

IPC

C07K5/97(2006-01-01)

C07K1/02(2006-01-01)

(21) (22)

Application

2014146802/04, 2014-11-21

(24)

Start date

2014-11-21

(22)

Actual filing date

2014-11-21

(45)

Published

2016-02-10

(72)

Inventor

Nazarenko Anna BorisovnaBalaev Aleksandr NikolaevichOkhmanovich Kirill Anatol'EvichFedorov Vladimir Egorovich

(73)

Holder

Diamondzlite Limited

METHOD FOR OBTAINING TREPEPTIDE OF GENERAL FORMULA (I) HPyr-His-TrpOH, APPLIED AS INTERMEDIATE COMPOUND (1-3 FRAGMENT) IN SYNTHESIS OF SYNTHETIC AGONISTS OF GONADOTROPIN-RELEASING-HORMONE (LH-RH), BY METHOD OF LIQUID-PHASE PEPTIDE SYNTHESIS WITHOUT PLACING AND REMOVAL OF PROTECTIVE GROUPS Russian patent published in 2016 - IPC C07K5/97 C07K1/02

Abstract RU 2574392 C1

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining HPyr-His-TrpOH applied as main semi-product (1-3 fragment) in synthesis of synthetic antagonists of gonadotropine-releasing-hormone, LH-RH. Tripeptide (I) is obtained by method of liquid-phase peptide synthesis without application of stages of placement and removal of protective groups.

EFFECT: method makes it possible to reduce quantity of synthesis stages, is more economically effective due to absence of placement and removal of protective groups stages and makes it possible to obtain tripeptide with high purity.

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RU 2 574 392 C1

Authors

Nazarenko Anna Borisovna

Balaev Aleksandr Nikolaevich

Okhmanovich Kirill Anatol'Evich

Fedorov Vladimir Egorovich

Dates

2016-02-10—Published

2014-11-21—Filed