METHOD FOR APPLYING PHOTODYNAMIC THERAPY AND ELECTROCHEMICAL DESTRUCTION IN CHOROID MELANOMA TREATMENT Russian patent published in 2007 - IPC A61F9/00 A61F9/07 A61F9/08 A61N1/18 A61N5/67 A61K31/409 A61P35/00 A61P27/00 

FIELD: medicine.

SUBSTANCE: method involves introducing photosensitizer in pharmaceutical water-soluble dosage form at a dose of 1.5-2.0 mg/kg * 0.7 during 40-60 min. Blood is concurrently exposed to laser radiation at a dose of 600-900 J/cm³. The wavelength is selected to match photosensitizer absorption maximum in the water-soluble dosage form. Chlorine row photosensitizer is introduced 3-3.5h later in liposome form at a dose of 1.5-2.0 mg/kg*0.3. 15 min later, laser radiation is applied all over the whole tumor perimeter in transpupillary mode with neighboring fields overlap by 5% of area with power density of 80-100 J/cm². The wavelength is selected to match photosensitizer absorption maximum in the liposome form. Then the whole neoplasm surface is irradiated in transpupillary mode in laser radiation fields in circle moving from periphery to the center with neighboring fields overlap being equal to 5% of area. The wavelength is selected to match photosensitizer absorption maximum in the water-soluble dosage form. Power density of 80-100 J/cm² in peripheral part is gradually increased when moving towards the center to 100-120 J/cm². Two weeks later, localization is adjusted in diaphanoscopic transscleral way and electrochemical destruction of intraocular neoplasm is carried out with current intensity of 10-100 mA during 10-1 min.

EFFECT: enhanced effectiveness in achieving complete or partial tumor regress; reduced risk of metastatic complications.

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