FIELD: medicine, oncology, pharmacology.
SUBSTANCE: invention involves creature of conjugate showing a broad spectrum of effect and showing selectivity and specificity of anti-angiogenic agents in combination with high effectiveness of cytotoxic preparations. Invention is based on using polypeptide-containing conjugate added covalently to cytotoxic chemical preparation molecule through an acid-labile bond using a cross-linking agent. Endostatin or angiostatin or their biologically active truncated fragments are used as polypeptide, and cytotoxic chemical preparation comprises at least one reactive amino-group. A cross-linking agent is chosen from group of dialdehydes and wherein the ratio of polypeptide to cytotoxic preparation = 1:(1-3). Invention provides the high anticancer activity against cancer cells of different strains and against endothelial cells also. Invention can be used as an anticancer medicinal agent of the direct effect.
EFFECT: valuable medicinal properties of conjugate.
2 cl, 3 tbl, 4 ex
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