FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, to obtaining compounds, to be exact, having an effect of angiogenesis inhibitors and can be used in medicine to treat the diseases accompanied by unbalanced vascularisation. The resulting fused protein consists of angiostanin and endostanin or biologically active fragments of angiostanin and endostanin covalently bonded with each other as well as with a sequence of aminoacids (Arg-Gly-Asp)n, where n=1-3 located on C- and/or N-end of the polypeptide chain and/or between sequences of angiostanin and endostanin and/or their fragments.
EFFECT: invention enables to obtain fused protein having an effect of angiogenesis inhibitors and with a high therapeutic effectiveness and a low level of side effects.
2 dwg, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CONJUGATE POSSESSING SELECTIVE EFFECT WITH RESPECT TO CANCER TUMORS | 2005 |
|
RU2303997C2 |
| ANGIOGENESIS INHIBITOR, ANTI-ANGIOGENIC PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF MALIGNANT NEOPLASM | 2005 |
|
RU2287341C1 |
| RECOMBINANT HYBRID INHIBITOR OF ANGIOGENESIS, AND ITS PRODUCTION METHOD | 2012 |
|
RU2499802C1 |
| RECOMBINANT HYBRID POLYPEPTIDE, CAPABLE OF INHIBITING HUMAN ENDOTHELIAL CELL PROLIFERATION IN VITRO, AND METHOD FOR PRODUCTION THEREOF | 2011 |
|
RU2465283C1 |
| ENHANCEMENT OF IMMUNE RESPONSES MEDIATED BY PROTEINS FUSED FROM ANTIBODY AND CYTOKINE BY METHOD OF COMBINED ADMINISTRATION OF ANGIOGENESIS INHIBITOR | 1999 |
|
RU2229305C2 |
| METHOD TO PRODUCE RECOMBINANT ANTI-ANGIOGENIC POLYPEPTIDE | 2012 |
|
RU2488635C1 |
| COMBINED THERAPY BY USING ANTIANGIOGENIC AGENTS AND TNF-ALPHA | 2002 |
|
RU2316337C2 |
| HOMODIMERIC FUSED PROTEIN WITH ACTIVITY OF ANGIOGENESIS INHIBITOR (VARIANTS), DNA MOLECULE ENCODING HOMODIMERIC FUSED PROTEIN, VECTOR FOR EXPRESSION OF HOMODIMERIC FUSED PROTEIN, METHOD FOR TRANSFECTION OF MAMMALIAN CELL AND METHOD FOR PREPARING HOMODIMERIC FUSED PROTEIN | 1999 |
|
RU2240328C2 |
| MULTIPURPOSE AND POLYVALENT INHIBITORS OF ANGIOGENESIS | 2005 |
|
RU2398878C2 |
| HUMAN ENDOSTATIN PREPARATION AND METHOD FOR PRODUCTION THEREOF | 2004 |
|
RU2278688C1 |
