POLYPEPTIDE DISPLAYING ANALOG OF RECEPTOR-BINDING EPIDERMAL GROWTH FACTOR FRAGMENT FROM 21 TO 31 AMINO ACIDS, ITS CONJUGATE WITH DOXORUBICIN AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2003 - IPC

Abstract RU 2196604 C1

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to polypeptide that is analog of epidermal growth factor fragment from 21-31 amino acids as vector used for directed delivery of antitumor preparations in tumor cells. Invention proposes also conjugate of polypeptide with doxorubicin showing selective effect with respect to cancer tumors. Pharmaceutical composition comprises effective amount of conjugate and carrier useful for intravenous administration. EFFECT: enhanced effectiveness of preparation effect. 4 cl, 3 tbl, 2 dwg, 6 ex

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RU 2 196 604 C1

Authors

Kiselev S.M.

Lutsenko S.V.

Severin E.S.

Severin S.E.

Fel'Dman N.B.

Dates

2003-01-20—Published

2001-12-21—Filed