2-METHYL-3-HYDROXY-4-FORMYL-5-HYDROXYMETHYLPYRIDINE β-HYDROXYNICOTINOYL HYDRAZONE DIHYDROCHLORIDE ELICITING ANTIOXIDANT, HEPATOPROTECTING AND IMMUNOMODULATING ACTIVITY Russian patent published in 2007 - IPC C07D401/12 

FIELD: organic chemistry, chemical technology, medicine.

SUBSTANCE: invention relates to novel biologically active chemical compounds, namely, to 2-methyl-3-hydroxy-4-formyl-5-hydroxypyridine β-hydroxynicotinoyl hydrazone dihydrochloride of the general formula (I): that possesses antioxidant, hepatoprotecting and immunomodulating effect. Compound of the formula (I) is synthesized by interaction of 5-hydroxynicotinic acid hydrazide with 2-methyl-3-hydroxy-4-formyl-5-hydroxypyridine hydrochloride at heating in the presence of a solvent and hydrochloric acid. Compound of the formula (I) induces the expressed stimulation of humoral response in rats. Mexidol as the known antioxidant doesn't possess such activity. By effect on the hypersensitivity response of delayed type compound of the formula (I) elicits the equal activity with mexidol. Compound of the formula (I) eliminates immunosuppressing effect arising in experimental acute pancreatitis and immunostimulation induced by administration of CCl₄ and it exceeds mexidol by its immunomodulating, antioxidant and hepatoprotecting effect in proposed models.

EFFECT: valuable medicinal properties of compound.

1 cl, 6 tbl, 1 ex