CULTURE VACCINE AGAINST POULTRY POX OUT OF HEN'S VIRUS (OSPOVAC) (VARIANTS) Russian patent published in 2007 - IPC A61K39/275 C12N7/00 A61P31/12 

FIELD: veterinary microbiology.

SUBSTANCE: according to the first variant, the vaccine suggested includes VGNKI-3/7 strain of hen's pox virus as a virus-containing material; as a stabilizer one should apply the mixture of peptone and lactose in 0.1-0.2M-phosphate buffer at pH being 7.0-7.4 at the following ratio of components, weight%: virus-containing material out of VGNKI-3/7 strain of hen's pox virus at infection activity being about 5.0-7.0 ID_{50/cu. cm} 65.0-70.0; peptone 4.0-10.0; lactose 5.0-10.0; 0.1-0.2M-phosphate buffer at pH 7.0-7.4 - the rest. According to the second variant, the vaccine suggested contains VGNKI-3/7 strain of hen's pox virus as virus-containing material, and as a stabilizer - glycerol at the following ratio of components, weight%: glycerol 5-10; virus-containing material out of VGNKI-3/7 of hen's pox virus at infection activity of 6.0-7.5 lg ID_{50/cu. cm} - the rest. The vaccine creates prolonged tense immunity.

EFFECT: higher efficiency.

3 cl, 9 ex, 1 tbl