FIELD: microbiology, in particular production of associated pertusis, diphtheria, and tetanum vaccine.
SUBSTANCE: claimed method includes blending of pertusis component, diphtheria and tetanum anatoxins; mixture sorption on aluminum hydroxide; mixture dosage into container, mixture lyophilizing and container sealing. As pertusis component cell-free pertusis anatoxin in concentration of 40-50 mug/ml is used. Mixture of cell-free pertusis anatoxin, diphtheria and tetanum anatoxins is sorbed on aluminum hydroxide. Then polyoxydonium as immunomodulator in amount of 0,5-0,52 mug/g in introduced into abovementioned mixture, mixture is held for 18-20 h at 4-10°C, sucrose is added up to finish concentration and mixture is held for 1 h at 4-10°C.
EFFECT: vaccine of decreased reactogenicity.
2 ex, 1 tbl
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